Investigation on the biological effects of low doses of I-131 and comparison with subjects occupationally exposed in the framework of nuclear medicine

The project deals with the evaluation of individual sensitivity, at molecular and chromosomal level, to low and high doses of ionizing and non-ionizing radiations, with the aim of investigating the impact of occupational exposures on the DNA repair efficiency. The project envisages a) molecular and cellular studies in cultures of lymphocytes from subjects exposed for occupational (MRI, X-rays, scintigraphy) or for diagnostic (low doses of I-131) purposes, and b) laboratory studies to evaluate whether low doses of ionizing or non-ionizing radiations, in the considered working environments, are able to modify the DNA repair capabilities and can be involved in protective (adaptive response) or pathologic processes.

Funding body: Italian Ministry of Foreign Affairs

Prime contractor: CNR - IREA and Institute of Nuclear Physics Henryk Niewodniczanski, Dept. of Environmental and Radiation Biology, Cracow, Poland

Period of activity: 2013 - 2015

IREA project manager: Maria Rosaria Scarfì

Research topic: Bioelectromagnetics